OTX008, a selective small-molecule inhibitor of galectin-1, downregulates cancer cell proliferation, invasion and tumour angiogenesis
Background: Galectin-1 (Gal1), a carbohydrate-binding protein is implicated in cancer cell proliferation, invasion and tumour angiogenesis. Several Gal1-targeting compounds have recently emerged. OTX008 is a calixarene derivative designed to bind the Gal1 amphipathic β-sheet conformation. Our study...
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| Autores principales: | Astorgues-Xerri, L., Riveiro, M.E., Tijeras-Raballand, A., Serova, M., Rabinovich, G.A., Bieche, I., Vidaud, M., de Gramont, A., Martinet, M., Cvitkovic, E., Faivre, S., Raymond, E. |
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| Formato: | INPR |
| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_09598049_v_n_p_AstorguesXerri |
| Aporte de: |
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