Histamine H4 receptor as a novel therapeutic target for the treatment of Leydig-cell tumours in prepubertal boys

Leydig-cell tumours (LCTs) are rare endocrine tumours of the testicular interstitium, with recent increased incidence. Symptoms include precocious puberty in children; and erectile dysfunction, infertility and/or gynaecomastia, in adults. So far, scientific evidence points to aromatase (CYP19) overe...

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Detalles Bibliográficos
Autores principales:	Abiuso, A.M.B., Varela, M.L., Haro Durand, L., Besio Moreno, M., Marcos, A., Ponzio, R., Rivarola, M.A., Belgorosky, A., Pignataro, O.P., Berensztein, E., Mondillo, C.
Formato:	JOUR
Materias:	Angiogenesis CYP19 aromatase Histamine Histamine receptor H4 Leydig-cell tumour Oestradiol Steroidogenesis androgen receptor cytochrome P450 family 19 estrogen receptor alpha estrogen receptor beta histamine H4 receptor somatomedin C receptor angiogenesis inhibitor antineoplastic agent AR protein, human aromatase clobenpropit CYP19A1 protein, human ESR2 protein, human estrogen receptor alpha, human guanidine derivative histamine agonist IGF1R protein, human imidazole derivative S-(2-guanidylethyl)isothiourea somatomedin receptor steroid synthesis inhibitor thiourea angiogenesis animal cell animal cell culture animal experiment animal model Article cell proliferation cell proliferation assay chorioallantoic membrane assay controlled study drug targeting human human cell human tissue immunohistochemistry in vitro study in vivo study Leydig cell tumor male nonhuman prepuberty priority journal protein expression R2C cell line rat reverse transcription polymerase chain reaction steroidogenesis testis tissue tumor cell umbilical vein endothelial cell Western blotting age agonists analogs and derivatives animal Coturnix drug effect embryology infant metabolism molecularly targeted therapy neovascularization (pathology) pathology signal transduction testis tumor tumor cell line Age Factors Angiogenesis Inhibitors Animals Antineoplastic Agents Aromatase Cell Line, Tumor Cell Proliferation Estrogen Receptor alpha Estrogen Receptor beta Guanidines Histamine Agonists Human Umbilical Vein Endothelial Cells Humans Imidazoles Infant Leydig Cell Tumor Male Molecular Targeted Therapy Neovascularization, Pathologic Rats Receptors, Androgen Receptors, Histamine H4 Receptors, Somatomedin Signal Transduction Steroid Synthesis Inhibitors Testicular Neoplasms Thiourea
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_09598049_v91_n_p125_Abiuso
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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