Structural basis of redox-dependent modulation of galectin-1 dynamics and function

Galectin-1 (Gal-1), a member of a family of multifunctional lectins, plays key roles in diverse biological processes including cell signaling, immunomodulation, neuroprotection and angiogenesis. The presence of an unusual number of six cysteine residues within Gal-1 sequence prompted a detailed anal...

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Detalles Bibliográficos
Autores principales: Guardia, C.M., Caramelo, J.J., Trujillo, M., Méndez-Huergo, S.P., Radi, R., Estrin, D.A., Rabinovich, G.A.
Formato: JOUR
Materias:
circular dichroism
cysteine
galectin-1
molecular dynamics
oxidation
arginine
carbohydrate
carbohydrate recognition domain
galectin 1
glutamic acid
hydrogen peroxide
lactose
polymer
unclassified drug
LGALS1 protein, human
amino acid sequence
article
binding affinity
cell viability
conformational transition
controlled study
disulfide bond
human
in vitro study
nonhuman
pH
priority journal
protein expression
protein function
protein interaction
protein structure
regulatory mechanism
structure activity relation
T lymphocyte
chemistry
metabolism
oxidation reduction reaction
protein tertiary structure
Galectin 1
Humans
Hydrogen Peroxide
Molecular Dynamics Simulation
Oxidation-Reduction
Protein Structure, Tertiary
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_09596658_v24_n5_p428_Guardia
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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