Improved bioavailability of inhibitors of Trypanosoma cruzi trans-sialidase: PEGylation of lactose analogs with multiarm polyethyleneglycol

The trans-sialidase of Trypanosoma cruzi (TcTS) catalyzes the transfer of sialic acid from host glycoconjugates to terminal β-galactopyranosides in the mucins of the parasite. During infection, the enzyme is actively shed by the parasite to the bloodstream inducing hematological alterations. Lactito...

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Detalles Bibliográficos
Autores principales: Giorgi, M.E., Ratier, L., Agusti, R., Frasch, A.C.C., De Lederkremer, R.M.
Formato: JOUR
Materias:
inhibitors
multiarm conjugates
PEGylation
trans-sialidase
Trypanosoma cruzi
disaccharide
lactose
macrogol
sialidase
animal experiment
animal model
apoptosis
article
bioavailability
cardiovascular system
controlled study
in vivo study
infection
molecular weight
mouse
nonhuman
nuclear magnetic resonance spectroscopy
parasite
plasma clearance
priority journal
Biological Availability
Dose-Response Relationship, Drug
Enzyme Inhibitors
Glycoproteins
Lactose
Magnetic Resonance Spectroscopy
Molecular Structure
Neuraminidase
Polyethylene Glycols
Structure-Activity Relationship
Mus
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_09596658_v22_n10_p1363_Giorgi
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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