Convergent evolution and mimicry of protein linear motifs in host-pathogen interactions

Pathogen linear motif mimics are highly evolvable elements that facilitate rewiring of host protein interaction networks. Host linear motifs and pathogen mimics differ in sequence, leading to thermodynamic and structural differences in the resulting protein-protein interactions. Moreover, the functi...

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Detalles Bibliográficos
Autores principales: Chemes, L.B., de Prat-Gay, G., Sánchez, I.E.
Formato: JOUR
Materias:
retinoblastoma binding protein
retinoblastoma protein
protein
adaptive evolution
binding affinity
coevolution
convergent evolution
evolutionary rate
genetic conservation
habitat selection
Helicobacter
host pathogen interaction
host resistance
human
Human adenovirus 5
Human papillomavirus type 16
Leptospira
linear motif mimicry
Metapneumovirus
molecular evolution
molecular mimicry
motif switch
negative purifying selection
nonhuman
phylogeny
physical chemistry
positive selection
priority journal
protein assembly
protein conformation
protein expression
protein function
protein linear motif
protein motif
protein protein interaction
protein secondary structure
protein structure, function and variability
purifying selection
Pyrenophora
regular expression
regulatory evolution
Review
sequence alignment
sequence analysis
Simian virus 40
animal
chemical structure
chemistry
genetics
metabolism
Eukaryota
Prokaryota
Amino Acid Motifs
Animals
Evolution, Molecular
Host-Pathogen Interactions
Humans
Models, Molecular
Molecular Mimicry
Protein Conformation
Protein Interaction Maps
Proteins
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_0959440X_v32_n_p91_Chemes
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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