Synthetic studies toward the preparation of (4R,5R)-(-)-3-[(benzyloxy) methyl]-4,5-O-isopropylidene-cyclopenten-2-one: An important synthetic intermediate for carbanucleosides

The carbocyclic compound (4R,5R)-(-)-3-[(benzyloxy)methyl]-4,5-O- isopropylidene-2-cyclopentenone 1 is an important synthetic intermediate to access a variety of carbanucleosides. Herein, synthetic studies that lead to this valuable compound employing inexpensive d-ribose as the chiral source are pr...

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Detalles Bibliográficos
Autores principales: Elhalem, E., Comin, M.J., Leitofuter, J., García-Liñares, G., Rodriguez, J.B.
Formato: JOUR
Materias:
3 [(benzyloxy)methyl] 4,5 o isopropylidene 2 cyclopentenone
carbocyclic nucleoside
cyclopentenone derivative
nucleoside derivative
ribose
unclassified drug
article
chirality
priority journal
synthesis
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_09574166_v16_n2_p425_Elhalem
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:The carbocyclic compound (4R,5R)-(-)-3-[(benzyloxy)methyl]-4,5-O- isopropylidene-2-cyclopentenone 1 is an important synthetic intermediate to access a variety of carbanucleosides. Herein, synthetic studies that lead to this valuable compound employing inexpensive d-ribose as the chiral source are presented. © 2004 Elsevier Ltd. All rights reserved.

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