Effect of the potent antiviral 1-cinnamoyl-3,11-dihydroxymeliacarpin on cytokine production by murine macrophages stimulated with HSV-2

The limonoid 1-cinnamoyl-3,11-dihydroxymeliacarpin (CDM) isolated from leaf extracts of Melia azedarach L, has potent antiherpetic effect in epithelial cells. Since Meliacine, the partially purified extract source of CDM, has therapeutic effect on murine genital herpes, the potential use of CDM as m...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Petrera, E., Coto, C.E.
Formato: JOUR
Materias:
cytokines
HSV-2
immunomodulator
tetranortriterpenoid
3 (4,5 dimethyl 2 thiazolyl) 2,5 diphenyltetrazolium bromide
acridine orange
antivirus agent
cytokine
gamma interferon
interleukin 10
interleukin 6
limonoid 1 cinnamoyl 3,11 dihydroxymeliacarpin
nitric oxide
tumor necrosis factor alpha
unclassified drug
animal cell
antiviral activity
article
controlled study
cytokine production
cytotoxicity test
drug determination
drug potency
enzyme linked immunosorbent assay
epithelium cell
female
Herpes simplex virus 2
macrophage activation
mouse
nonhuman
plant leaf
protein expression
Vero cell
virus inhibition
virus plaque
virus replication
Herpes
Human herpesvirus 2
Melia azedarach
Murinae
Simplexvirus
Animals
Antiviral Agents
Cercopithecus aethiops
Cytokines
Herpesvirus 2, Human
Inhibitory Concentration 50
Interferon-gamma
Interleukin-10
Interleukin-6
Limonins
Macrophages
Mice
Nitric Oxide
Tumor Necrosis Factor-alpha
Vero Cells
Virus Replication
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_0951418X_v28_n1_p104_Petrera
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

Ejemplares similares

Ejemplares similares