Fetal but not adult Leydig cells are susceptible to adenoma formation in response to persistently high hCG level: A study on hCG overexpressing transgenic mice

We have previously demonstrated that male transgenic (TG) mice overexpressing human chorionic gonadotropin (hCG+) develop reproductive organ defects, but no tumors, in adult age. In this study, the effects of persistently elevated hCG were followed in TG males between day 5 postpartum and adulthood....

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Detalles Bibliográficos
Autores principales: Ahtiainen, P., Rulli, S.B., Shariatmadari, R., Pelliniemi, L.J., Toppari, J., Poutanen, M., Huhtaniemi, I.T.
Formato: JOUR
Materias:
Adult Leydig cell
Fetal Leydig cell
hCG
Tumor
3beta hydroxy delta5 steroid dehydrogenase
chorionic gonadotropin
isoenzyme
luteinizing hormone receptor
prostaglandin D synthase
testosterone
thrombospondin 2
adenoma
adulthood
age distribution
animal cell
animal experiment
animal model
animal tissue
article
cancer susceptibility
carcinogenesis
concentration (parameters)
concentration response
controlled study
developmental stage
fetus
fetus cell
gender
gene overexpression
human
Leydig cell
male
marker gene
mutation
nonhuman
nucleotide sequence
perinatal period
phenotype
prepuberty
priority journal
protein expression
puerperium
testosterone blood level
transgenic mouse
wild type
3-Hydroxysteroid Dehydrogenases
Adenoma
Animals
Chorionic Gonadotropin, beta Subunit, Human
Fetus
Gene Expression Regulation, Developmental
Gene Expression Regulation, Neoplastic
Glycoprotein Hormones, alpha Subunit
Humans
Intramolecular Oxidoreductases
Leydig Cells
Male
Mice
Mice, Transgenic
Phenotype
Testis
Thrombospondins
Up-Regulation
Animalia
Mus musculus
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_09509232_v24_n49_p7301_Ahtiainen
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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