Herpes simplex virus thymidine kinase/ganciclovir system in multicellular tumor spheroids

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We have developed multicellular spheroids (MCS) established from LM05e and LM3 spontaneous Balb/c-murine mammary adenocarcinoma and B16 C57-murine melanoma derived cell lines as an in vitro model to study the efficacy of the herpes simplex virus thymidine kinase/ganciclovir (HSVtk/GCV) suicide syste...

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Detalles Bibliográficos
Autores principales: Finocchiaro, L.M.E., Bumaschny, V.F., Karara, A.L., Fiszman, G.L., Casais, C.C., Glikin, G.C.
Formato: JOUR
Materias:
Lipofection
Murine adenocarcinoma
Suicide gene therapy
ganciclovir
suicide substrate
thymidine kinase
animal cell
animal tissue
apoptosis
article
breast adenocarcinoma
bystander effect
cell growth
cell proliferation
cell specificity
cell type
controlled study
drug cytotoxicity
drug efficacy
gene expression regulation
gene transfer
Herpes simplex virus
in vitro study
in vivo study
intracellular transport
melanoma cell
mitochondrion
monolayer culture
mouse
multicellular spheroid
nonhuman
phenotype
population structure
priority journal
protein assembly
sensitivity analysis
statistical significance
transgene
virus resistance
Adenocarcinoma
Animals
Antiviral Agents
bcl-2-Associated X Protein
beta-Galactosidase
Bystander Effect
Cell Division
Cell Line, Tumor
Drug Resistance
Ganciclovir
Gene Therapy
Mammary Neoplasms, Animal
Melanoma
Mice
Mice, Inbred BALB C
Proto-Oncogene Proteins c-bcl-2
Simplexvirus
Spheroids, Cellular
Thymidine Kinase
Transfection
Viral Proteins
Animalia
Murinae
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_09291903_v11_n5_p333_Finocchiaro
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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