Superoxide dismutase 1 expression is modulated by the core pluripotency transcription factors Oct4, Sox2 and Nanog in embryonic stem cells

Redox homeostasis is vital for cellular functions and to prevent the detrimental consequences of oxidative stress. Pluripotent stem cells (PSCs) have an enhanced antioxidant system which supports the preservation of their genome. Besides, reactive oxygen species (ROS) are proposed to be involved in...

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Detalles Bibliográficos
Autores principales: Solari, C., Petrone, M.V., Vazquez Echegaray, C., Cosentino, M.S., Waisman, A., Francia, M., Barañao, L., Miriuka, S., Guberman, A.
Formato: JOUR
Materias:
Antioxidant defense system
Cu-Zn Sod
Sod1
Transcriptional regulation
copper zinc superoxide dismutase
messenger RNA
mitochondrial DNA
octamer transcription factor 4
short hairpin RNA
transcription factor NANOG
transcription factor Sox2
Article
binding site
blastocyst
cardiac muscle cell
cell differentiation
cell growth
cell nucleus
cell self-renewal
controlled study
cytoplasm
down regulation
embryonic stem cell
gene
gene expression
gene mutation
human
human cell
in vitro study
nerve cell
oxidative stress
priority journal
promoter region
protein expression
protein targeting
smooth muscle cell
sod1 gene
transcription regulation
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_09254773_v154_n_p116_Solari
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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