Antiherpetic mode of action of (22S,23S)-3β-bromo-5α,22,23- trihydroxystigmastan-6-one in vitro

The replication of herpes simplex virus (HSV) type 1 in Vero cells is inhibited in the presence of (22S,23S)-3β-bromo-5α,22,23- trihydroxystigmastan-6-one (6b), a synthetic brassinosteroid derivative. Attempts to disclose the mode of action of 6b indicate that a late step of virus multiplication is...

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Detalles Bibliográficos
Autores principales: Wachsman, M.B., Castilla, V., Talarico, L.B., Ramirez, J.A., Galagovsky, L.R., Coto, C.E.
Formato: JOUR
Materias:
(22S,23S)-3β- Bromo-5α,22,23-trihydroxystigmastan-6-one
Antiviral
Brassinosteroid derivatives
Herpes simplex
3beta bromo 5alpha,22,23 trihydroxystigmastan 6 one
antivirus agent
brassinosteroid
unclassified drug
animal cell
antigen expression
article
controlled study
drug mechanism
Herpes simplex virus 1
immunofluorescence test
in vitro study
nonhuman
priority journal
protein synthesis
Vero cell
virus replication
Animals
Antigens, Viral
Antiviral Agents
Cercopithecus aethiops
Cholestanones
Fluorescent Antibody Technique, Indirect
Herpesvirus 1, Human
Transcription, Genetic
Vero Cells
Viral Proteins
Virus Replication
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_09248579_v23_n5_p524_Wachsman
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:The replication of herpes simplex virus (HSV) type 1 in Vero cells is inhibited in the presence of (22S,23S)-3β-bromo-5α,22,23- trihydroxystigmastan-6-one (6b), a synthetic brassinosteroid derivative. Attempts to disclose the mode of action of 6b indicate that a late step of virus multiplication is affected. In the presence of 6b, HSV late protein synthesis was severely diminished and this inhibitory effect of 6b on HSV antigen expression was confirmed by immunofluorescence assays. © 2004 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

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