Dopamine Regulation of Lateral Inhibition between Striatal Neurons Gates the Stimulant Actions of Cocaine

Striatal medium spiny neurons (MSNs) form inhibitory synapses on neighboring striatal neurons through axon collaterals. The functional relevance of this lateral inhibition and its regulation by dopamine remains elusive. We show that synchronized stimulation of collateral transmission from multiple i...

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Detalles Bibliográficos
Autores principales: Dobbs, L.K., Kaplan, A.R., Lemos, J.C., Matsui, A., Rubinstein, M., Alvarez, V.A.
Formato: JOUR
Materias:
cocaine
dopamine
dopamine 2 receptor
adult
animal cell
animal experiment
animal tissue
Article
axon
brain nerve cell
controlled study
corpus striatum
female
gene deletion
locomotion
male
mouse
nerve potential
nerve stimulation
nerve tract
nonhuman
nucleus accumbens
priority journal
regulatory mechanism
striatal medium spiny neuron
synaptic inhibition
synaptic transmission
ventral pallidum
action potential
animal
central nervous system sensitization
cytology
dose response
drug effects
knockout mouse
metabolism
nerve cell inhibition
physiology
transgenic mouse
Action Potentials
Animals
Central Nervous System Sensitization
Cocaine
Corpus Striatum
Dopamine
Dose-Response Relationship, Drug
Locomotion
Mice
Mice, Knockout
Mice, Transgenic
Neural Inhibition
Nucleus Accumbens
Receptors, Dopamine D2
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_08966273_v90_n5_p1100_Dobbs
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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