Enhanced GABA Transmission Drives Bradykinesia Following Loss of Dopamine D2 Receptor Signaling

Bradykinesia is a prominent phenotype of Parkinson's disease, depression, and other neurological conditions. Disruption of dopamine (DA) transmission plays an important role, but progress in understanding the exact mechanisms driving slowness of movement has been impeded due to the heterogeneit...

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Detalles Bibliográficos
Autores principales:	Lemos, J.C., Friend, D.M., Kaplan, A.R., Shin, J.H., Rubinstein, M., Kravitz, A.V., Alvarez, V.A.
Formato:	JOUR
Materias:	dopamine 2 receptor 4 aminobutyric acid dopamine animal experiment animal tissue Article bradykinesia brain nerve cell controlled study corpus striatum depletion dopaminergic transmission GABAergic transmission gene deletion globus pallidus in vivo study indirect pathway medium spiny neuron locomotion mouse mouse model nerve cell nerve cell membrane potential nonhuman Parkinson disease priority journal signal transduction animal hypokinesia metabolism physiology substantia nigra transgenic mouse Animals Corpus Striatum Dopamine gamma-Aminobutyric Acid Globus Pallidus Hypokinesia Mice, Transgenic Neurons Parkinson Disease Receptors, Dopamine D2 Signal Transduction Substantia Nigra
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_08966273_v90_n4_p824_Lemos
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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