Kinetic and mechanistic studies on the hydrolysis and photodegradation of diazepam and alprazolam

The corresponding o-aminobenzophenones are usually reported as the main degradation products in the hydrolysis of 1,4-benzodiazepinones. Nevertheless, in previous studies of diazepam (DZ) in acidic aqueous medium we isolated and characterized seven unexpected degradation products. Kinetic measuremen...

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Detalles Bibliográficos
Autores principales: Cabrera, C.G., Goldberg De Waisbaum, R., Nudelman, N.S.
Formato: JOUR
Materias:
Alprazolam
Anxiolytics
Benzodiazepinone pharmaceuticals
Diazepam
Drug stability
Hydrolysis
Photosensitivity
Photostability
Electron transitions
Mass spectrometry
Nuclear magnetic resonance spectroscopy
Oxidation
pH effects
Photodegradation
Reaction kinetics
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_08943230_v18_n2_p156_Cabrera
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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