Loss of Feedback Inhibition via D2 Autoreceptors Enhances Acquisition of Cocaine Taking and Reactivity to Drug-Paired Cues

A prominent aspect of drug addiction is the ability of drug-associated cues to elicit craving and facilitate relapse. Understanding the factors that regulate cue reactivity will be vital for improving treatment of addictive disorders. Low availability of dopamine (DA) D2 receptors (D2Rs) in the stri...

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Detalles Bibliográficos
Autores principales: Holroyd, K.B., Adrover, M.F., Fuino, R.L., Bock, R., Kaplan, A.R., Gremel, C.M., Rubinstein, M., Alvarez, V.A.
Formato: JOUR
Materias:
autoreceptor
cocaine
dopamine
dopamine 2 receptor
dopamine uptake inhibitor
DRD2 protein, mouse
animal
association
cocaine dependence
disease model
drug effects
drug self administration
feedback system
genetics
instrumental conditioning
knockout mouse
male
mesencephalon
metabolism
nerve cell
nerve cell inhibition
physiology
Animals
Autoreceptors
Cocaine
Cocaine-Related Disorders
Conditioning, Operant
Cues
Disease Models, Animal
Dopamine
Dopamine Uptake Inhibitors
Feedback, Physiological
Male
Mesencephalon
Mice, Knockout
Neural Inhibition
Neurons
Receptors, Dopamine D2
Self Administration
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_0893133X_v40_n6_p1495_Holroyd
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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