Carbonic anhydrase inhibitor acetazolamide shifts synaptic vesicle recycling to a fast mode at the mouse neuromuscular junction

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Acetazolamide (AZ), a molecule frequently used to treat different neurological syndromes, is an inhibitor of the carbonic anhydrase (CA), an enzyme that regulates pH inside and outside cells. We combined fluorescent FM styryl dyes and electrophysiological techniques at ex vivo levator auris longus n...

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Detalles Bibliográficos
Autores principales: Bertone, N.I., Groisman, A.I., Mazzone, G.L., Cano, R., Tabares, L., Uchitel, O.D.
Formato: JOUR
Materias:
bromophenol
endocytosis
endplate potentials
exocytosis
FM styryl dyes
myosin light chain kinase
synaptophysin-pHluorin
transmitter release
acetazolamide
bromophenol blue
dye
carbonate dehydratase inhibitor
cardiac myosin
muscle relaxant agent
myosin light chain
myosin light chain 2
acidification
animal cell
animal tissue
Article
controlled study
endplate potential
enzyme activation
enzyme phosphorylation
evoked response
ex vivo study
fluorescence analysis
immunohistochemistry
male
motor end plate
mouse
neuromuscular junction
neurotransmitter release
nonhuman
priority journal
synapse vesicle
synaptic transmission
animal
C57BL mouse
cytology
cytosol
drug effects
membrane potential
metabolism
pH
phosphorylation
physiology
transgenic mouse
Acetazolamide
Animals
Carbonic Anhydrase Inhibitors
Cardiac Myosins
Cytosol
Exocytosis
Hydrogen-Ion Concentration
Male
Membrane Potentials
Mice, Inbred C57BL
Mice, Transgenic
Myosin Light Chains
Myosin-Light-Chain Kinase
Neuromuscular Agents
Neuromuscular Junction
Phosphorylation
Synaptic Vesicles
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_08874476_v71_n12_p_Bertone
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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