Exploring the molecular basis of heme coordination in human neuroglobin

Neuroglobin (Ngb), a recently discovered ancient heme protein, presents the typical globin fold and is around 20% identical to myoglobin (Mb). In contrast with Mb, however, its heme is hexacoordinated (6c). It is expressed in the nervous system and has been the subject of numerous investigations in...

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Detalles Bibliográficos
Autores principales: Nadra, A.D., Martí, M.A., Pesce, A., Bolognesi, M., Estrin, D.A.
Formato: JOUR
Materias:
Globin
Heme protein
Hexacoordination
Molecular dynamics
Neuroglobin
cysteine
disulfide
heme
hemoprotein
histidine
iron
myoglobin
neuroglobin
oxygen
protein
reactive oxygen metabolite
article
comparative study
detoxification
hypoxia
kinetics
molecular biology
molecular dynamics
molecular stability
oxidation reduction reaction
oxidation reduction state
oxygen transport
priority journal
protein analysis
protein expression
protein structure
sampling
sensor
Animals
Computer Simulation
Crystallography, X-Ray
Globins
Heme
Histidine
Humans
Ligands
Mice
Models, Molecular
Nerve Tissue Proteins
Protein Binding
Protein Conformation
Thermodynamics
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_08873585_v71_n2_p695_Nadra
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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