Enzyme replacement therapy in porphyrias. V. In vivo correction of δ-aminolaevulinate dehydratase defective in erythrocytes in lead intoxicated animals by enzyme-loaded red blood cell ghosts

Resealed erythrocyte ghosts are potential in vivo carriers of exogenous therapeutic enzymes. In the present work, the effect of administering δ-aminolaevulinate dehydratase (ALA-D) encapsulated in autologous red blood cell ghosts (RBCg) to lead intoxicated and normal mice was investigated. Administr...

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Detalles Bibliográficos
Autores principales:	Bustos, N.L., Del Batlle, C.A.M.
Formato:	JOUR
Materias:	Aminolevulic acid dehydratase Enzyme replacement therapy Lead intoxication Porphyrias Red blood cell ghosts porphobilinogen synthase animal experiment animal model article autologous blood bioavailability blood level congenital disorder erythrocyte ghost head intoxication intravenous drug administration kidney liver mouse nonhuman porphyria priority journal spleen Animal Erythrocyte Membrane Erythrocytes Female Lead Poisoning Mice Mice, Inbred Strains Porphobilinogen Synthase Porphyria Support, Non-U.S. Gov't
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_08842884_v5_n2_p125_Bustos
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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