In Vitro Uptake of Benzodiazepines by Rat Pineal Gland

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As a part of a study aiming to characterize the physiological and pharmacological significance of the high affinity pineal benzodiazepine (BZP) binding sites reported previously, we examined the uptake of the BZP derivative 3H‐flunitrazepam (FNZP) by rat pineal glands in vitro. At 37 °C, 3H‐radioact...

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Detalles Bibliográficos
Autores principales: Lowenstein, P.R., Solveyra, C.G., Cardinali, D.P.
Formato: JOUR
Materias:
benzodiazepine uptake
diurnal rhythms
pineal gland
superior cervical ganglionectomy
benzodiazepine
benzodiazepine receptor
radioisotope
animal cell
central nervous system
circadian rhythm
drug accumulation
drug receptor binding
endocrine system
flunitrazepam h 3
nonhuman
pharmacokinetics
pineal body
rat
Animal
Biological Transport
Cerebral Cortex
Female
Flunitrazepam
Kinetics
Organ Specificity
Pineal Gland
Rats
Rats, Inbred Strains
Receptors, GABA-A
Support, Non-U.S. Gov't
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_07423098_v1_n3_p207_Lowenstein
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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