VIP boosts regulatory T cell induction by trophoblast cells in an in vitro model of trophoblast–maternal leukocyte interaction

Inducible regulatory T cells (Tregs) exert a timely and efficient immunosuppressive action at the critical peri-implantation stage essential for maternal tolerance to the conceptus. Vasoactive intestinal peptide (VIP) promotes anti-inflammatory and tolerogenic profiles through binding to VIP recepto...

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Detalles Bibliográficos
Autores principales:	Fraccaroli, L., Grasso, E., Hauk, V., Paparini, D., Soczewski, E., Mor, G., Leirós, C.P., Ramhorst, R.
Formato:	JOUR
Materias:	Early pregnancy iTreg TGF-β Tolerance CD4 antigen gamma interferon interleukin 10 interleukin 17 polypeptide transcription factor FOXP3 transforming growth factor beta transforming growth factor beta antibody vasoactive intestinal polypeptide vasoactive intestinal polypeptide antagonist vasoactive intestinal polypeptide receptor transforming growth factor beta1 Article cell interaction cell population cell suspension coculture controlled study cytokine production DNA cross linking DNA synthesis female first trimester pregnancy human human cell immune response in vitro study intracellular space leukocyte peripheral blood mononuclear cell priority journal regulatory T lymphocyte trophoblast biosynthesis cell communication cell line cytology drug effects immunology metabolism pregnancy real time polymerase chain reaction Cell Communication Cell Line Coculture Techniques Female Humans In Vitro Techniques Interleukin-10 Leukocytes Pregnancy Pregnancy Trimester, First Real-Time Polymerase Chain Reaction T-Lymphocytes, Regulatory Transforming Growth Factor beta1 Trophoblasts Vasoactive Intestinal Peptide
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_07415400_v98_n1_p49_Fraccaroli
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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