Adrenal gland involvement in the regulation of renal 11 β-hydroxysteroid dehydrogenase 2

Renal 11 β-hydroxysteroid dehydrogenase 2 (HSD2) catalyzes the conversion of active glucocorticoids to inert 11 β-keto compounds, thereby preventing the illicit binding of these hormones to mineralocorticoid receptors (MRs) and, thus, conferring aldosterone specificity. Absence or inhibition of HSD2...

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Detalles Bibliográficos
Autores principales: Zallocchi, M.L., Matkovic, L., Calvo, J.C., Damasco, M.C.
Formato: JOUR
Materias:
Acidosis
Corticosterone
HSD2
Kidney
Stress
11beta hydroxysteroid dehydrogenase
chloride
corticosterone
glucocorticoid
adrenal gland
adrenalectomy
animal experiment
animal model
article
body weight
controlled study
enzyme activity
enzyme regulation
feeding
metabolic acidosis
nonhuman
priority journal
radioimmunoassay
rat
stress
Western blotting
animal
blood
enzymology
gene expression regulation
kidney
kinetics
metabolism
physiology
Animalia
11-beta-Hydroxysteroid Dehydrogenase Type 2
Adrenal Glands
Adrenalectomy
Animals
Gene Expression Regulation, Enzymologic
Kinetics
Models, Animal
Rats
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_07302312_v92_n3_p591_Zallocchi
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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