The 21-aminosteroid U-74389F attenuates hyperexpression of GAP-43 and NADPH-diaphorase in the spinal cord of wobbler mouse, a model for amyotrophic lateral sclerosis

The wobbler mouse suffers an autosomal recessive mutation producing severe neurodegeneration and astrogliosis in spinal cord. It has been considered a model for amyotrophic lateral sclerosis. We have studied in these animals the expression of two proteins, the growth-associated protein (GAP-43) and...

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Detalles Bibliográficos
Autores principales: González Deniselle, M.C., González, S.L., Lima, A.E., Wilkin, G., De Nicola, A.F.
Formato: JOUR
Materias:
21-aminosteroids
GAP-43
NADPH-diaphorase
Neurogeneration
Wobbler mouse
21 [4 [2,6 bis(1 pyrrolidinyl) 4 pyrimidinyl] 1 piperazinyl]pregna 1,4,9(11) triene 3,20 dione
21 aminosteroid
neuromodulin
reduced nicotinamide adenine dinucleotide phosphate dehydrogenase
amyotrophic lateral sclerosis
animal experiment
animal model
article
controlled study
drug effect
enzyme inhibition
glia cell
immunocytochemistry
motoneuron
mouse
nerve fiber regeneration
nerve sprouting
nonhuman
oxidative stress
priority journal
protein expression
spinal cord
Amyotrophic Lateral Sclerosis
Animals
Antioxidants
Dihydrolipoamide Dehydrogenase
Disease Models, Animal
Female
GAP-43 Protein
Gene Expression Regulation
Humans
Male
Mice
Mice, Neurologic Mutants
Motor Neurons
Pregnatrienes
Spinal Cord
Animalia
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_03643190_v24_n1_p1_GonzalezDeniselle
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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