Nitric oxide reduces paracellular resistance in rat thick ascending limbs by increasing Na+ and Cl- permeabilities

About 50% of the Na+ reabsorbed in thick ascending limbs traverses the paracellular pathway. Nitric oxide (NO) reduces the permselectivity of this pathway via cGMP, but its effects on absolute Na+ (PNa +) and Cl- (PCl -) permeabilities are unknown. To address this, we measured the effect of L-argini...

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Detalles Bibliográficos
Autores principales: Monzon, C.M., Occhipinti, R., Pignataro, O.P., Garvin, J.L.
Formato: JOUR
Materias:
Kidney
Nitric oxide
Paracellular permeability
Sodium transport
chloride
nitric oxide
sodium
arginine
cyclic GMP
enzyme inhibitor
n(g) nitroarginine methyl ester
nitric oxide synthase
animal experiment
Article
cell membrane permeability
conductance
controlled study
electric potential
limb
male
Michaelis Menten kinetics
nonhuman
osmolality
priority journal
rat
steady state
transcytosis
transepithelial resistance
velocity
animal
antagonists and inhibitors
biological model
drug effects
Henle loop
impedance
in vitro study
kidney tubule absorption
metabolism
perfusion
permeability
Sprague Dawley rat
transport at the cellular level
Animals
Arginine
Biological Transport
Chlorides
Cyclic GMP
Electric Impedance
Enzyme Inhibitors
In Vitro Techniques
Loop of Henle
Male
Models, Biological
NG-Nitroarginine Methyl Ester
Nitric Oxide
Nitric Oxide Synthase
Perfusion
Permeability
Rats, Sprague-Dawley
Renal Reabsorption
Sodium
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_03636127_v312_n6_pF1035_Monzon
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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