Interplay between lysosomal, mitochondrial and death receptor pathways during manganese-induced apoptosis in glial cells

Manganese (Mn) is an essential trace metal which plays a critical role in brain physiology by acting as a cofactor for several enzymes. However, upon overexposure, Mn preferentially accumulates within the basal ganglia leading to the development of a Parkinsonism known as Manganism. Data from our gr...

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Detalles Bibliográficos
Autores principales: Gorojod, R.M., Alaimo, A., Porte Alcon, S., Saravia, F., Kotler, M.L.
Formato: JOUR
Materias:
Apoptosis
Cathepsins
Glia
Lysosomes
Manganese
Parkinsonism
bafilomycin A1
caspase 3
caspase 7
caspase 8
caspase 9
cathepsin
cathepsin B
cathepsin D
cytochrome c
death receptor
Fas ligand
manganese
pepstatin
protein Bid
Bid protein, rat
macrolide
Tnfsf6 protein, rat
animal cell
animal experiment
animal model
animal tissue
apoptosis
Article
controlled study
corpus striatum
cytosol
enzyme activation
enzyme release
glia cell
immunocytochemistry
immunohistochemistry
in vivo study
lysosome
lysosome membrane
male
membrane permeability
mitochondrion
molecular biology
nonhuman
oxidative stress
priority journal
protein cleavage
protein expression
protein transport
rat
substantia nigra pars compacta
upregulation
Western blotting
animal
drug effect
glia
metabolism
pathology
physiology
signal transduction
Sprague Dawley rat
tumor cell line
Animals
BH3 Interacting Domain Death Agonist Protein
Caspase 3
Caspase 7
Cathepsin D
Cell Line, Tumor
Cytosol
Fas Ligand Protein
Macrolides
Male
Mitochondria
Neuroglia
Protein Transport
Rats, Sprague-Dawley
Signal Transduction
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_03405761_v91_n9_p3065_Gorojod
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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