Effects of chronic treatments with adrenal steroids on acid-base homeostasis in the rat
Urinary parameters related to acid-base homeostasis were studied in adrenalectomized rats (ADX) as well as in ADX treated with physiological doses of corticosterone (B), aldosterone (aldo) or 18-Hydroxycorticosterone (18HOB) during 1, 3 or 5 days, under basal conditions and after gravage with 200 mM...
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| Autores principales: | , , |
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| Formato: | JOUR |
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_03276309_v46_n3_p149_Igarreta |
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| Sumario: | Urinary parameters related to acid-base homeostasis were studied in adrenalectomized rats (ADX) as well as in ADX treated with physiological doses of corticosterone (B), aldosterone (aldo) or 18-Hydroxycorticosterone (18HOB) during 1, 3 or 5 days, under basal conditions and after gravage with 200 mM HCl. The results showed: a) a persistent effect of B and 18HOB increasing titratable acidity principally in response to acidosis; b) an increased phosphate elimination in acidotic B treated ADX on the first day, and in 18HOB treated ADX on days 3 and 5; c) pronounced increases in blood pH and blood bicarbonate levels provoked by the three steroids on day 1; d) increments of ammonium elimination in response to acidosis by aldo treatment on the first day, while B and 18HOB increase ammonium elimination under almost all conditions during the whole experiment; e) the effects of B and 18HOB would be independent of an increase in sodium retention as well as glomerular filtration rate. |
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