Erythrocyte uroporphyrinogen I synthase in rats treated with the hepatic carcinogen diethylnitrosamine

Uroporphyrinogen I Synthase (URO-S) activity was measured in erythrocytes of female and male rats which had received diethylnitrosamine (DENA) as an inducer of hepatic tumors. Twenty-two weeks after the last dose of the carcinogen, the rats showed statistically significant increases in the URO-S act...

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Detalles Bibliográficos
Autores principales: De Calmanovici, R.W., Cochon, A.C., Aldonatti, C.A., Cabral, J.R.P., San Martin De Viale, L.C.
Formato: JOUR
Materias:
diethylnitrosamine
hepatic tumors
porphyrins
rats
uroporphyrinogen I synthase
porphobilinogen deaminase
porphyrin
animal cell
animal experiment
animal model
article
controlled study
enzyme activity
erythrocyte
female
liver tumor
male
nonhuman
rat
Animal
Carcinoma, Hepatocellular
Diethylnitrosamine
Erythrocytes
Female
Hydroxymethylbilane Synthase
Liver Neoplasms
Male
Rats
Support, Non-U.S. Gov't
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_03276309_v45_n1_p49_DeCalmanovici
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Uroporphyrinogen I Synthase (URO-S) activity was measured in erythrocytes of female and male rats which had received diethylnitrosamine (DENA) as an inducer of hepatic tumors. Twenty-two weeks after the last dose of the carcinogen, the rats showed statistically significant increases in the URO-S activity. Differences in the body weight, erythrocyte porphyrin content or the hematocrit between treated and control rats were not found. Fifty percent of female rats and thirty percent of male rats treated with DENA were found to have hepatic tumors but there was no correlation between blood URO-S-activity and tumoral development in spite of the increase in UROS-S activity observed in DENA treated rats. This was observed both in male and female rats.

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