Regulated Necrosis Orchestrates Microglial Cell Death in Manganese-Induced Toxicity

Microglia, the brain resident immune cells, play prominent roles in immune surveillance, tissue repair and neural regeneration. Despite these pro-survival actions, the relevance of these cells in the progression of several neuropathologies has been established. In the context of manganese (Mn) overe...

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Detalles Bibliográficos
Autores principales: Porte Alcon, S., Gorojod, R.M., Kotler, M.L.
Formato: JOUR
Materias:
lysosomes, regulated necrosis
manganese
Manganism
microglia
parthanatos
cathepsin D
nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase 1
reactive oxygen metabolite
animal cell
apoptosis
Article
cell death
cell disruption
cell structure
cell viability
DNA damage
genotoxicity
human
human cell
lysosome
MTT assay
nonhuman
priority journal
signal transduction
animal
cell survival
drug effect
metabolism
mitochondrion
mouse
necrosis
Animals
Apoptosis
Cell Death
Cell Survival
Lysosomes
Manganese
Mice
Microglia
Mitochondria
Necrosis
Reactive Oxygen Species
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_03064522_v393_n_p206_PorteAlcon
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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