In vivo prevention and reversal by the antimitotic colchicine and other related compounds of some porphyrinogenic drug action on heme pathway

1. The effect of colchicine, vincristin and griseofulvin (GRIS) on the porphyrinogenic action of 2-allyl-2-isopropylacetamide (AIA) and veronal was studied in vivo and using the in vitro experimental model of tissue explant cultures. 2. Complete prevention by colchicine was found in liver and heart...

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Detalles Bibliográficos
Autores principales: Afonso, S.G., Polo, C.F., Navone, N.M., Vazquez, E.S., Buzaleh, A.M., Schoua, E., Alcira Maria, d.C.B.
Formato: JOUR
Materias:
allylisopropylacetamide
barbital
colchicine
griseofulvin
lactate dehydrogenase
porphyrin
vincristine
animal cell
animal experiment
article
heart
heme synthesis
intraperitoneal drug administration
liver
male
mouse
nonhuman
porphyria
priority journal
skin
tissue culture
5-Aminolevulinate Synthetase
Allylisopropylacetamide
Animal
Colchicine
Enzyme Induction
Griseofulvin
Heme
In Vitro
Lactate Dehydrogenase
Male
Mice
Porphyrins
Support, Non-U.S. Gov't
Vincristine
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_03063623_v21_n4_p423_Afonso
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:1. The effect of colchicine, vincristin and griseofulvin (GRIS) on the porphyrinogenic action of 2-allyl-2-isopropylacetamide (AIA) and veronal was studied in vivo and using the in vitro experimental model of tissue explant cultures. 2. Complete prevention by colchicine was found in liver and heart explant from animals treated with AIA and veronal. 3. Vincristin, GRIS and colchicine reversed AIA induction in liver explants, however reversal was partial or nil in skin and heart explants depending on the antimitotic and the tissue. 4. The usefulness of the combination of the in vivo experimental model and the in vitro explant tissue culture model, for this kind of studies is emphasized. © 1990.

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