Drug metabolizing enzyme system and heme pathway in hepatocarcinogenesis

Chemically induced and spontaneous liver tumors share some metabolic alterations. The decline in hemoprotein levels during hepatocarcinogenesis may result from a diminution of the intracellular heme pool. To elucidate if the onset of the pre-initiation stage alters the natural regulation mechanism o...

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Detalles Bibliográficos
Autores principales: Vazquez, E., Gerez, E., Caballero, F., Polo, C., Batlle, A.
Formato: JOUR
Materias:
δ-Aminolevulinic acid synthase
2-allylisopropyl-acetamide
Cytochrome P-450
Gluthatione S-transferase
Hepatocarcinogenesis
Microsomal heme oxygenase
4 dimethylaminoazobenzene
5 aminolevulinate synthase
allylisopropylacetamide
beta glucuronidase
carcinogen
cytochrome P450
enzyme inhibitor
glutathione transferase
heme
heme oxygenase
hemoprotein
prodrug
sulfatase
tryptophan 2,3 dioxygenase
animal
article
biological model
biotransformation
cell transformation
chemically induced disorder
comparative study
drug antagonism
drug effect
drug resistance
enzyme induction
enzymology
liver microsome
liver tumor
male
metabolism
mouse
oxidation reduction reaction
physiology
precancer
5-Aminolevulinate Synthetase
Allylisopropylacetamide
Animals
Biotransformation
Carcinogens
Cell Transformation, Neoplastic
Cytochrome P-450 Enzyme System
Drug Resistance
Enzyme Induction
Enzyme Inhibitors
Glucuronidase
Glutathione Transferase
Heme
Heme Oxygenase (Decyclizing)
Hemeproteins
Liver Neoplasms, Experimental
Male
Mice
Microsomes, Liver
Models, Biological
Oxidation-Reduction
p-Dimethylaminoazobenzene
Precancerous Conditions
Prodrugs
Sulfatases
Tryptophan Oxygenase
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_03057232_v17_n1-2_p25_Vazquez
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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