Regulation of heme pathway in regenerating mouse liver

1. 1. δ-Aminolevulinic acid synthetase (ALA-S), rhodanese and microsomal heme oxygenase (MHO), were quantitated in Cl4C induced regenerating mouse liver. 2. 2. Maximal hepatomegalia was observed at 48 hr after i.p. injection of a single dose of the toxin. 3. 3. ALA-S activity decreased on day 2, and...

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Detalles Bibliográficos
Autores principales: Polo, C.F., Vazquez, E.S., Del Battle, C.A.M.
Formato: JOUR
Materias:
5 aminolevulinate synthase
carbon tetrachloride
heme oxygenase
thiosulfate sulfurtransferase
animal experiment
animal tissue
article
liver regeneration
liver toxicity
mouse
nonhuman
priority journal
5-Aminolevulinate Synthetase
Aminolevulinic Acid
Animal
Carbon Tetrachloride
Cytochrome P-450 Enzyme System
Heme
Heme Oxygenase (Decyclizing)
Kinetics
Liver
Liver Regeneration
Mice
Microsomes, Liver
Porphyrins
Support, Non-U.S. Gov't
Thiosulfate Sulfurtransferase
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_03050491_v101_n1-2_p243_Polo
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:1. 1. δ-Aminolevulinic acid synthetase (ALA-S), rhodanese and microsomal heme oxygenase (MHO), were quantitated in Cl4C induced regenerating mouse liver. 2. 2. Maximal hepatomegalia was observed at 48 hr after i.p. injection of a single dose of the toxin. 3. 3. ALA-S activity decreased on day 2, and then significantly increased (50%) between days 3 and 7, returning afterwards to control values. 4. 4. Cytoplasmic rhodanese, as well as MHO activities, exhibited a clear correlation as compared with the ALA-S activity profile. 5. 5. Porphyrin biosynthesis from precursor δ-aminolevulinic acid (ALA) was significantly increased even after 15 days of intoxication. 6. 6. Present results would indicate that Cl4C is acting in a dual fashion. © 1992.

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