Inhibition of platelet-derived growth factor (PDGF) receptor affects follicular development and ovarian proliferation, apoptosis and angiogenesis in prepubertal eCG-treated rats

The platelet-derived growth factor (PDGF) system is crucial for blood vessel stability. In the present study, we evaluated whether PDGFs play a critical intraovarian survival role in gonadotropin-dependent folliculogenesis. We examined the effect of intrabursal administration of a selective platelet...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Pascuali, N., Scotti, L., Abramovich, D., Irusta, G., Di Pietro, M., Bas, D., Tesone, M., Parborell, F.
Formato:	JOUR
Materias:	Angiogenesis Apoptosis Folliculogenesis Ovary Platelet-derived growth factor 6,7 dimethyl 2 phenylquinoxaline caspase 3 caspase 8 chorionic gonadotropin estradiol phosphatidylinositol 3 kinase platelet derived growth factor receptor progesterone protein BAD protein Bax protein bcl 2 protein kinase B 6,7-dimethoxy-2-phenylquinoxaline platelet derived growth factor tyrphostin angiogenesis animal cell animal experiment animal tissue apoptosis Article cell proliferation cell survival controlled study DNA extraction DNA fragmentation endothelium cell female immunohistochemistry morphology nonhuman organ weight ovary ovary follicle cell ovary follicle development pericyte prepuberty priority journal protein expression protein phosphorylation radioimmunoassay rat vascular smooth muscle cell Western blotting animal antagonists and inhibitors cytology horse ovary follicle physiology sexual maturation Sprague Dawley rat vascularization Animals Cell Proliferation Chorionic Gonadotropin Female Horses Neovascularization, Physiologic Ovarian Follicle Platelet-Derived Growth Factor Rats, Sprague-Dawley Receptors, Platelet-Derived Growth Factor Sexual Maturation Tyrphostins
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_03037207_v412_n_p148_Pascuali
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

Ejemplares similares

Inhibition of platelet-derived growth factor (PDGF) receptor affects follicular development and ovarian proliferation, apoptosis and angiogenesis in prepubertal eCG-treated rats
Publicado: (2015)

Involvement of the ANGPTs/Tie-2 system in ovarian hyperstimulation syndrome (OHSS)
Publicado: (2013)

Involvement of the ANGPTs/Tie-2 system in ovarian hyperstimulation syndrome (OHSS)
por: Scotti, L., et al.

Local administration of platelet-derived growth factor B (PDGFB) improves follicular development and ovarian angiogenesis in a rat model of Polycystic Ovary Syndrome
por: di Pietro, María Florencia, et al.
Publicado: (2016)

Local administration of platelet-derived growth factor B (PDGFB) improves follicular development and ovarian angiogenesis in a rat model of Polycystic Ovary Syndrome
por: Di Pietro, M., et al.

Metformin regulates ovarian angiogenesis and follicular development in a female polycystic ovary syndrome rat model
por: di Pietro, María Florencia, et al.
Publicado: (2015)

Metformin regulates ovarian angiogenesis and follicular development in a female polycystic ovary syndrome rat model
por: Di Pietro, M., et al.

Intrabursal injection of vascular endothelial growth factor trap in eCG-treated prepubertal rats inhibits proliferation and increases apoptosis of follicular cells involving the PI3K/AKT signaling pathway
Publicado: (2010)

Intrabursal injection of vascular endothelial growth factor trap in eCG-treated prepubertal rats inhibits proliferation and increases apoptosis of follicular cells involving the PI3K/AKT signaling pathway
por: Abramovich, D., et al.

Effect of a vascular endothelial growth factor (VEGF) inhibitory treatment on the folliculogenesis and ovarian apoptosis in gonadotropin-treated prepubertal rats
Publicado: (2006)

Effect of a vascular endothelial growth factor (VEGF) inhibitory treatment on the folliculogenesis and ovarian apoptosis in gonadotropin-treated prepubertal rats
por: Abramovich, D., et al.

Inhibin A increases apoptosis in early ovarian antral follicles of diethylstilbestrol-treated rats
Publicado: (2002)

Inhibin A increases apoptosis in early ovarian antral follicles of diethylstilbestrol-treated rats
por: Vitale, A.M., et al.

Local VEGF inhibition prevents ovarian alterations associated with ovarian hyperstimulation syndrome
por: Abramovich, Dalhia Nurit, et al.
Publicado: (2014)

Local VEGF inhibition prevents ovarian alterations associated with ovarian hyperstimulation syndrome
por: Scotti, L., et al.

Spatiotemporal analysis of the protein expression of angiogenic factors and their related receptors during folliculogenesis in rats with and without hormonal treatment
por: Abramovich, Dalhia Nurit, et al.
Publicado: (2009)

Spatiotemporal analysis of the protein expression of angiogenic factors and their related receptors during folliculogenesis in rats with and without hormonal treatment
por: Abramovich, D., et al.

Regulation of ovarian angiogenesis and apoptosis by GnRH-I analogs
por: Parborell, M.Fernanda A., et al.
Publicado: (2008)

Regulation of ovarian angiogenesis and apoptosis by GnRH-I analogs
por: Parborell, F., et al.

Intrabursal administration of the antiangiopoietin 1 antibody produces a delay in rat follicular development associated with an increase in ovarian apoptosis mediated by changes in the expression of BCL2 related genes
por: Parborell, M.Fernanda A., et al.
Publicado: (2008)

Intrabursal administration of the antiangiopoietin 1 antibody produces a delay in rat follicular development associated with an increase in ovarian apoptosis mediated by changes in the expression of BCL2 related genes
por: Parborell, F., et al.
Publicado: (2008)

Intrabursal administration of the antiangiopoietin 1 antibody produces a delay in rat follicular development associated with an increase in ovarian apoptosis mediated by changes in the expression of BCL2 related genes
por: Parborell, F., et al.

Intrabursal administration of the antiangiopoietin 1 antibody produces a delay in rat follicular development associated with an increase in ovarian apoptosis mediated by changes in the expression of BCL2 related genes
por: Parborell, F., et al.
Publicado: (2008)

Gonadotropin-releasing hormone agonist affects rat ovarian follicle development by interfering with FSH and growth factors on the prevention of apoptosis
por: Parborell, M.Fernanda A., et al.
Publicado: (2001)

Gonadotropin-releasing hormone agonist affects rat ovarian follicle development by interfering with FSH and growth factors on the prevention of apoptosis
por: Parborell, F., et al.

Platelet-derived growth factor BB and DD and angiopoietin1 are altered in follicular fluid from polycystic ovary syndrome patients
Publicado: (2014)

Platelet-derived growth factor BB and DD and angiopoietin1 are altered in follicular fluid from polycystic ovary syndrome patients
por: Scotti, L., et al.

Regulation of ovarian follicle differentiation in gonadotrophin-stimulated rats
por: Andreu, Claudia Viviana, et al.
Publicado: (1997)

Regulation of ovarian follicle differentiation in gonadotrophin-stimulated rats
por: Andreu, C.V., et al.

Angiopoietin 1 reduces rat follicular atresia mediated by apoptosis through the PI3K/Akt pathway
Publicado: (2011)

Angiopoietin 1 reduces rat follicular atresia mediated by apoptosis through the PI3K/Akt pathway
por: Parborell, F., et al.

Effects of a gonadotropin-releasing hormone agonist on rat ovarian follicle apoptosis: Regulation by epidermal growth factor and the expression of Bcl-2-related genes
Publicado: (2002)

Effects of a gonadotropin-releasing hormone agonist on rat ovarian follicle apoptosis: Regulation by epidermal growth factor and the expression of Bcl-2-related genes
por: Parborell, F., et al.

Expression of fragile X mental retardation protein and Fmr1 mRNA during folliculogenesis in the rat
por: Parborell, M.Fernanda A., et al.
Publicado: (2013)

Expression of fragile X mental retardation protein and Fmr1 mRNA during folliculogenesis in the rat
por: Ferder, I., et al.

Gonadotropin-releasing hormone antagonist antide inhibits apoptosis of preovulatory follicle cells in rat ovary
Publicado: (2005)

Gonadotropin-releasing hormone antagonist antide inhibits apoptosis of preovulatory follicle cells in rat ovary
por: Parborell, F., et al.

Angiopoietins/TIE2 system and VEGF are involved in ovarian function in a DHEA rat model of polycystic ovary syndrome
Publicado: (2012)

Angiopoietins/TIE2 system and VEGF are involved in ovarian function in a DHEA rat model of polycystic ovary syndrome
por: Abramovich, D., et al.

Altered expression of Bcl-2 and Bax in follicles within dehydroepiandrosterone-induced polycystic ovaries in rats
por: Abramovich, Dalhia Nurit, et al.
Publicado: (2011)