Insulin, glucose and glycated hemoglobin in Alzheimer's and vascular dementia with and without superimposed Type II diabetes mellitus condition

Increased concentrations of insulin, glucose and glycohemoglobin are associated with Type II diabetes mellitus (DM) and recognized as characteristic markers of the disease; in Alzheimer's (AD), Vascular dementia (VaD), and both dementia's with superimposed diabetes (AD + DM, VaD + DM) the...

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Detalles Bibliográficos
Autores principales: Domínguez, R.O., Marschoff, E.R., Guareschi, E.M., Repetto, M.G., Famulari, A.L., Pagano, M.A., Serra, J.A., Bartolomé, E.L., González, S., D'Abraccio, G., Arata, M., Oudkerk, L., Garau, L., Krinsky, F., Labos, E., Ruiz, C., Frechtel, G., Arana, A., Lovecchio, S.
Formato: JOUR
Materias:
Alzheimer's disease
Dementia risk factors
Glucose
Glycated hemoglobin
Insulin
Non-insulin-dependent Type II diabetes mellitus
Vascular dementia
glucose
glycosylated hemoglobin
insulin
aged
Alzheimer disease
analysis of variance
article
comparative study
controlled study
correlation analysis
female
glucose blood level
hemoglobin blood level
human
insulin blood level
major clinical study
male
multiinfarct dementia
non insulin dependent diabetes mellitus
priority journal
statistics
Aged
Alzheimer Disease
Blood Glucose
Brain
Dementia, Vascular
Diabetes Mellitus, Type 2
Female
Hemoglobin A, Glycosylated
Humans
Magnetic Resonance Imaging
Male
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_03009564_v115_n1_p77_Dominguez
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Increased concentrations of insulin, glucose and glycohemoglobin are associated with Type II diabetes mellitus (DM) and recognized as characteristic markers of the disease; in Alzheimer's (AD), Vascular dementia (VaD), and both dementia's with superimposed diabetes (AD + DM, VaD + DM) the knowledge is scarce. The sample (n = 122; males = 60; mean age = 73 ± 7) comprised DM, AD, VaD, AD + DM, and VaD + DM patients, and healthy controls (C). The ANOVA's yielded significant differences between groups: Insulin p = 3.7 × 10 -3; Glucose p < 10-12; Glycohemoglobin p = 9.2×10-4. Comparisons between groups (DM vs. C, AD + DM vs. AD, VaD + DM vs. VaD, and demented DM vs. non-demented DM) resulted significant for all variables (Bonferroni's statistic, α = 0.05). Diabetic and diabetic demented patients presented significant increases largely different from controls (0.01 < p < 0.001), unlike the non-significant changes in their non-diabetic counterparts; linear relationships were found across all groups. The correlation's insulin/glucose and insulin/glycohemoglobin change to positive within demented groups, indicating a different performance of insulin in demented and non-demented subjects. © 2007 Springer-Verlag.

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