Role of UTX in retinoic acid receptor-mediated gene regulation in leukemia

Human UTX, a member of the Jumonji C family of proteins, associates with mixed-lineage leukemia 3/4 complexes. Stimulation with retinoic acid leads to the recruitment of UTX-containing complexes to HOX genes, which results in demethylation of histone H3 lysine 27 and concomitant methylation of histo...

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Detalles Bibliográficos
Autores principales:	Rocha-Viegas, L., Villa, R., Gutierrez, A., Iriondo, O., Shiekhattar, R., Croce, L.D.
Formato:	JOUR
Materias:	histone H3 lysine protein retinoic acid retinoic acid receptor alpha unclassified drug utx protein antineoplastic agent ASH2L protein, human DNA binding protein histone histone demethylase nuclear protein retinoic acid receptor transcription factor UTX protein, human Article cell differentiation cell maturation chromatin immunoprecipitation controlled study flow cytometry fluorescence activated cell sorting gene activation gene control gene expression gene overexpression gene silencing gene targeting genetic transcription genetic transfection human human cell immunoprecipitation in vivo study promoter region promyelocytic leukemia protein depletion protein interaction quantitative analysis retrovirus infection reverse transcription polymerase chain reaction transcription initiation U937 cell line article drug effect gene expression regulation genetics HEK293 cell line leukemia metabolism pathology tumor cell line Antineoplastic Agents Cell Differentiation Cell Line, Tumor DNA-Binding Proteins Gene Expression Regulation, Neoplastic Gene Knockdown Techniques HEK293 Cells Histone Demethylases Histones Humans Leukemia Nuclear Proteins Promoter Regions, Genetic Receptors, Retinoic Acid Transcription Factors Tretinoin U937 Cells
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_02707306_v34_n19_p3765_RochaViegas
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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