RSUME enhances glucocorticoid receptor SUMOylation and transcriptional activity

Glucocorticoid receptor (GR) activity is modulated by posttranslational modifications, including phosphorylation, ubiquitination, and SUMOylation. The GR has three SUMOylation sites: lysine 297 (K297) and K313 in the N-terminal domain (NTD) and K721 within the ligand-binding domain. SUMOylation of t...

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Detalles Bibliográficos
Autores principales: Druker, J., Liberman, A.C., Antunica-Noguerol, M., Gerez, J., Paez-Pereda, M., Rein, T., Iñiguez-Lluhí, J.A., Holsboer, F., Arzta, E.
Formato: JOUR
Materias:
glucocorticoid receptor
nuclear receptor coactivator 2
small interfering RNA
article
controlled study
female
gene activity
gene expression
gene mutation
gene silencing
genetic transcription
human
human cell
in vitro study
priority journal
protein interaction
protein processing
sumoylation
Animals
Arginine
Carrier Proteins
Cell Line
Cercopithecus aethiops
COS Cells
Heat-Shock Response
Mutation
Nerve Tissue Proteins
Protein Structure, Tertiary
Rats
Receptors, Glucocorticoid
Sumoylation
Transcription Factors
Transcriptional Activation
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_02707306_v33_n11_p2116_Druker
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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