Heregulin induces transcriptional activation of the progesterone receptor by a mechanism that requires functional ErbB-2 and mitogen-activated protein kinase activation in breast cancer cells

The present study addresses the capacity of heregulin (HRG), a ligand of type I receptor tyrosine kinases, to transactivate the progesterone receptor (PR). For this purpose, we studied, on the one hand, an experimental model of hormonal carcinogenesis in which the synthetic progestin medroxyprogeste...

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Detalles Bibliográficos
Autores principales:	Labriola, L., Salatino, M., Proietti, C.J., Pecei, A., Coso, O.A., Kornblihtt, A.R., Charreau, E.H., Elizalde, P.V.
Formato:	JOUR
Materias:	2 (2 amino 3 methoxyphenyl)chromone antisense oligodeoxynucleotide epidermal growth factor receptor 2 gestagen medroxyprogesterone acetate mifepristone mitogen activated protein kinase mitogen activated protein kinase 1 neu differentiation factor progesterone progesterone receptor protein tyrosine kinase receptor unclassified drug animal cell article autoradiography binding site breast adenocarcinoma breast cancer cancer cell culture carcinogenesis cell nucleus controlled study DNA protein complex down regulation enzyme activation enzyme activity genetic transfection molecular mechanics mouse nonhuman priority journal protein expression protein phosphorylation transactivation transcription initiation Animals Breast Neoplasms Cell Division Cell Nucleus Enzyme Inhibitors Female Flavonoids Genes, erbB-2 Hormone Antagonists Humans Mammary Neoplasms, Experimental Mice Mice, Inbred BALB C Mifepristone Mitogen-Activated Protein Kinases Neuregulin-1 Phosphorylation Receptor, erbB-2 Receptors, Progesterone RNA, Messenger RNA, Neoplasm Trans-Activation (Genetics) Tumor Cells, Cultured Animalia Eukaryota Felis catus Murinae
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_02707306_v23_n3_p1095_Labriola
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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