A gain-of-function mutation in the α9 nicotinic acetylcholine receptor alters medial olivocochlear efferent short-term synaptic plasticity

Gain control of the auditory system operates at multiple levels. Cholinergic medial olivocochlear (MOC) fibers originate in the brainstem and make synaptic contacts at the base of the outer hair cells (OHCs), the final targets of several feedback loops from the periphery and higher-processing center...

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Detalles Bibliográficos
Autores principales: Wedemeyer, C., Vattino, L.G., Moglie, M.J., Ballestero, J., Maison, S.F., Di Guilmi, M.N., Taranda, J., Liberman, M.C., Fuchs, P.A., Katz, E., Elgoyhen, A.B.
Formato: JOUR
Materias:
Cochlea
Efferent inhibition
Hair cells
Synaptic plasticity
α9α10 nAChR
alpha9 nicotinic acetylcholine receptor
nicotinic receptor
unclassified drug
animal cell
animal tissue
Article
calcium signaling
cochlea
controlled study
efferent nerve
enzyme activation
facilitation
feedback system
female
gain of function mutation
hyperpolarization
induced pluripotent stem cell
male
medial olivocochlear efferent
mouse
nerve cell plasticity
nonhuman
outer hair cell
phenotype
priority journal
short term synaptic plasticity
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_02706474_v38_n16_p3939_Wedemeyer
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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