Activated by evoked released protons modulate synaptic transmission at the mouse calyx of held synapse

Acid-sensing ion channels (ASICs) regulate synaptic activities and play important roles in neurodegenerative diseases. We found that these channels can be activated in neurons of the medial nucleus of the trapezoid body (MNTB) of the auditory system in the CNS. A drop in extracellular pH induces tra...

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Detalles Bibliográficos
Autores principales:	González-Inchauspe, C., Urbano, F.J., Di Guilmi, M.N., Uchitel, O.D.
Formato:	JOUR
Materias:	ASIC-1a Calyx of held Glutamatergic EPSCs Protons Short-term depression Synaptic plasticity acid sensing ion channel amiloride AMPA receptor antiporter creatine phosphate glutamate receptor glutamic acid postsynaptic receptor Accn2 protein, mouse proton acidification action potential animal experiment Article cell membrane permeability depolarization depression desensitization drug mechanism electrophysiology evoked response female fluorescence glutamatergic synapse male mouse nerve cell plasticity nerve ending neurotransmitter release nonhuman patch clamp technique priority journal synapse synaptic transmission animal auditory evoked potential C57BL mouse channel gating chemistry cochlear nucleus metabolism pH physiology Acid Sensing Ion Channels Animals Cochlear Nucleus Evoked Potentials, Auditory Female Hydrogen-Ion Concentration Ion Channel Gating Male Mice Mice, Inbred C57BL Neuronal Plasticity Synapses Synaptic Transmission
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_02706474_v37_n10_p2589_GonzalezInchauspe
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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