A potential tolerogenic immune mechanism in a trophoblast cell line through the activation of chemokine-induced T cell death and regulatory T cell modulation

BACKGROUND: Successful implantation is followed by a local pro-inflammatory and Th1 response, subsequently controlled by Th2. Regulated upon activation, normal T cell expressed and secreted (RANTES) promotes a Th1 response and is implicated as a physiologic tolerogenic factor; therefore, we studied...

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Detalles Bibliográficos
Autores principales: Fraccaroli, L., Alfieri, J., Larocca, L., Calafat, M., Mor, G., Leirós, C.P., Ramhorst, R.
Formato: JOUR
Materias:
Chemokines
Recurrent spontaneous miscarriages
T cell
Tolerance and pregnancy
CD4 antigen
chemokine
gamma interferon
interleukin 12p70
leukemia inhibitory factor
lipocortin 5
nitrite
progesterone
RANTES
transcription factor FOXP3
tumor necrosis factor alpha
apoptosis
article
CD3+ T lymphocyte
CD4+ CD25+ Foxp3+ T lymphocyte
cell death
cell proliferation
cell selection
cell strain Swan 7I
cell survival
clinical article
coculture
enzyme linked immunosorbent assay
female
fluorescence activated cell sorting
human
human cell
immune response
kinetics
leukemia
leukocyte
peripheral blood mononuclear cell
regulatory T lymphocyte
spontaneous abortion
T lymphocyte activation
trophoblast
Western blotting
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_02681161_v24_n1_p166_Fraccaroli
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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