α-Difluoromethylornithine-resistant cell lines obtained after one-step selection of Leishmania mexicana promastigote cultures

Proliferation of Leishmania mexicana promastigotes in synthetic medium can be blocked by the depletion of intracellular polyamine pools induced by the presence of D,L-α-difluoromethylornithine (DFMO), a specific and irreversible inhibitor of ornithine decarboxylase (ODC). Here we report that DEMO-re...

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Detalles Bibliográficos
Autores principales:	Sánchez, C.P., Mucci, J., González, N.S., Ochoa, A., Zakin, M.M., Algranati, I.D.
Formato:	JOUR
Materias:	antitrypanosomal agent eflornithine messenger RNA ornithine ornithine decarboxylase ornithine decarboxylase inhibitor article binding affinity cell culture cell selection controlled study drug resistance drug uptake enzyme activity enzyme inhibitor interaction enzyme specificity gene amplification Leishmania mexicana nonhuman priority journal promastigote
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_02646021_v324_n3_p847_Sanchez
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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