Synthesis and biological evaluation of salpichrolide analogs as antiestrogenic agents

The antiestrogenic activity of three natural salpichrolides A, G and B (1, 3 and 4) and of five synthetic analogs containing an aromatic D ring and a simplified side chain (5-9), was evaluated on MCF-7 cells. The 2,3-ene-1-keto steroids 8 and 9 were obtained from 3β-acetoxy-17(13→18)-abeo- 5αH-pregn...

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Detalles Bibliográficos
Autores principales: Sonego, J.M., Rivero, E.M., Gargiulo, L., Lüthy, I., Alvarez, L.D., Veleiro, A.S., Burton, G.
Formato: JOUR
Materias:
Antiestrogenic activity
Antiproliferative activity
Salpichrolides
Withanolides
17(13-18)abeo 5alphah pregna 2,13,15,17 tetraen 1,20 dione
1alpha hydroxy 17(13-18) abeo 5alphah pregna 2,13,15,17 tetraen 20 one
20 (tert butyldimethylsilyloxy) 17 (13-18) abeo 5alphah pregna 13,15,17 trien 3beta ol
20 acetoxy 17(13-18) abeo 5alphah pregna 2,13,15,17 tetraen 1alpha ol
20 acetoxy 17(13-18)abeo 5alphah pregna 13,15,17 trien 3 one
20 acetoxy 17(13-18)abeo5alphah pregna 1,13,15,17 tetraen 3 one
20 acetoxy 1alpha,2alpha epoxy 17(13-18)abeo 5alphah pregna 13,15,17 trien 3 one
3beta acetoxy 20 (tert butyldimethylsilyloxy) 17 (13-18)abeo 5alphah pregna 13,15,17 triene
antiestrogen
antineoplastic hormone agonists and antagonists
fulvestrant
salpichrolide A
salpichrolide B
salpichrolide derivative
salpichrolide G
unclassified drug
ergosterol
antiestrogenic activity
antineoplastic activity
antiproliferative activity
apoptosis
article
breast cancer
cell proliferation
controlled study
cytotoxicity
drug activity
drug screening
drug structure
drug synthesis
estrogen activity
genetic algorithm
human
human cell
MCF 7 cell line
analogs and derivatives
chemical structure
chemistry
dose response
drug effects
structure activity relation
synthesis
tumor cell culture
Antineoplastic Agents, Hormonal
Cell Proliferation
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Ergosterol
Estrogen Antagonists
Humans
MCF-7 Cells
Molecular Structure
Structure-Activity Relationship
Tumor Cells, Cultured
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_02235234_v82_n_p233_Sonego
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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