Superoxide scavenging and antimicrobial activities of novel transition metal complexes of oxydiacetate dianion as primary ligand: Spectral characterization, cyclic voltammetric investigations and crystal structure
Complexes of stoichiometries [M(oda)(4-pic)H 2 O]·xH 2 O [M = Cu(1), x = 2; Co (2), x = 4; Ni (3), x = 2; ] [Fe(oda)(4-pic)]·Cl (4) and {[Cu(2-pa) 2 ]·2H 2 O} n (5) (H 2 oda = oxydiacetic acid, 4-pic = 4-picoline and 2-paH = 2-picolinic acid) were prepared to explore their uses as possible models fo...
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| Autores principales: | , , , , , , |
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| Formato: | JOUR |
| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_02235234_v57_n_p102_Siddiqi |
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| Sumario: | Complexes of stoichiometries [M(oda)(4-pic)H 2 O]·xH 2 O [M = Cu(1), x = 2; Co (2), x = 4; Ni (3), x = 2; ] [Fe(oda)(4-pic)]·Cl (4) and {[Cu(2-pa) 2 ]·2H 2 O} n (5) (H 2 oda = oxydiacetic acid, 4-pic = 4-picoline and 2-paH = 2-picolinic acid) were prepared to explore their uses as possible models for mono- and poly-nuclear metallo-pharmaceuticals. The chemical structures were elucidated by IR, FAB-Mass, 1 H, 13 C NMR, EPR and UV-visible (ligand field) spectral analyses. Electrochemical investigations are consistent with formation of stable quasi-reversible redox Co II/III and Cu II/III couples in the solution. Single crystal X-ray data of the complex (5) indicated a 1D coordination polymeric structure with extensive H-bonding to form supramolecular frameworks. The antimicrobial activities were examined against Escherichia coli (k-12), Bacillus subtilis (MTC-121), Staphylococcus aureus (IOASA-22), Salmonella typhimurium (MTCC-98), Candida albicans, Aspergillus fumigatus and Penicillium marneffei. The superoxide dismutase (SOD) activities of the Cu(II) complexes (1 and 5) were assessed employing nitrobluetetrazolium (NBT) assay. © 2012 Elsevier Masson SAS. All rights reserved. |
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