How Are Short Exons Flanked by Long Introns Defined and Committed to Splicing?

The splice sites (SSs) delimiting an intron are brought together in the earliest step of spliceosome assembly yet it remains obscure how SS pairing occurs, especially when introns are thousands of nucleotides long. Splicing occurs in vivo in mammals within minutes regardless of intron length, implyi...

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Detalles Bibliográficos
Autores principales: Hollander, D., Naftelberg, S., Lev-Maor, G., Kornblihtt, A.R., Ast, G.
Formato: JOUR
Materias:
RNA polymerase II
small nuclear ribonucleoprotein
splicing factor U2AF
U2AF2 protein, human
carboxy terminal sequence
chromatin
chromatin structure
exon
genetic model
genetic transcription
human
in vivo study
intron
kinetics
length
molecular evolution
priority journal
Review
RNA binding
RNA splicing
RNA synthesis
spliceosome
genetics
Chromatin
Exons
Humans
Introns
Ribonucleoprotein, U1 Small Nuclear
Ribonucleoproteins, Small Nuclear
RNA Polymerase II
RNA Splicing
Spliceosomes
Splicing Factor U2AF
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_01689525_v32_n10_p596_Hollander
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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