Reduced virulence of a Junin virus mutant is associated with restricted multiplication in murine cells

C167, a mutant derived from the XJC13 strain of Junin virus, is highly attenuated in its pathogenic properties for newborn mice. Whereas 102 PFU of XJC13 injected intracerebrally killed 100% of two-day-old mice, the mutant showed no detectable lethality. Survival of mice infected with C167 was assoc...

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Detalles Bibliográficos
Autores principales: Scolaro, L.A., Mersich, S.E., Damonte, E.B.
Formato: JOUR
Materias:
Arenavirus
Argentine hemorrhagic fever
Attenuated mutant
Junin virus
Mouse virulence
Restricted multiplication in murine cells
animal experiment
arenavirus
cell culture
junin virus
mouse
nonhuman
priority journal
virus attenuation
virus mutant
virus replication
virus virulence
Animal
Animals, Newborn
Arenaviridae
Arenaviruses, New World
Hemorrhagic Fever, American
Interferons
Mice
Mutation
Support, Non-U.S. Gov't
Virulence
Virus Replication
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_01681702_v13_n4_p283_Scolaro
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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