Reversal of antiprogestin resistance and progesterone receptor isoform ratio in acquired resistant mammary carcinomas

To explore mechanisms related to hormone resistance, three resistant variants of the MPA mouse breast cancer tumor model with low levels of progesterone receptor (PR) isoform A (PR-A)/high PR-B expression were developed by prolonged selective pressure with antiprogestins. The resistant phenotype of...

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Detalles Bibliográficos
Autores principales:	Wargon, V., Helguero, L.A., Bolado, J., Rojas, P., Novaro, V., Molinolo, A., Lanari, C.
Formato:	JOUR
Materias:	Acquired hormone resistance AKT Antiprogestins Breast cancer De novo hormone resistance ERK Estrogen receptors Hormone resistance Metastasis Progesterone receptor isoforms Tumor regression estradiol estrogen receptor alpha lonaprisan mifepristone mitogen activated protein kinase 1 mitogen activated protein kinase 3 progesterone receptor A progesterone receptor B protein kinase B tamoxifen hormone antagonist isoprotein progesterone receptor animal experiment animal model animal tissue article axillary lymph node breast cancer breast carcinoma cancer inhibition cancer resistance controlled study female lymph node metastasis metastasis potential mouse nonhuman priority journal tumor growth animal Bagg albino mouse cell proliferation drug resistance experimental neoplasm fluorescent antibody technique metabolism pathology survival rate Western blotting Animals Blotting, Western Cell Proliferation Drug Resistance, Neoplasm Female Fluorescent Antibody Technique Hormone Antagonists Lymphatic Metastasis Mammary Neoplasms, Experimental Mice Mice, Inbred BALB C Mifepristone Mitogen-Activated Protein Kinase 1 Mitogen-Activated Protein Kinase 3 Protein Isoforms Proto-Oncogene Proteins c-akt Receptors, Progesterone Survival Rate
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_01676806_v116_n3_p449_Wargon
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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