CDK5-mediated phosphorylation of p19INK4d avoids DNA damage-induced neurodegeneration in mouse hippocampus and prevents loss of cognitive functions

DNA damage, which perturbs genomic stability, has been linked to cognitive decline in the aging human brain, and mutations in DNA repair genes have neurological implications. Several studies have suggested that DNA damage is also increased in brain disorders such as Alzheimer's disease, Parkins...

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Detalles Bibliográficos
Autores principales:	Ogara, M.F., Belluscio, L.M., de la Fuente, V., Berardino, B.G., Sonzogni, S.V., Byk, L., Marazita, M., Cánepa, E.T.
Formato:	JOUR
Materias:	Apoptosis Beta amyloid peptide DNA damage Learning and memory Neocarzinostatin Neurodegeneration calcium cyclin dependent kinase 5 cyclin dependent kinase inhibitor 2D DNA RNA amyloid beta protein amyloid beta-protein (25-35) Cdk5 protein, mouse Cdkn2d protein, mouse cytotoxin peptide fragment zinostatin animal cell animal experiment animal model apoptosis article calcium cell level cell survival cognitive defect controlled study DNA repair embryo female genotoxicity hippocampal neuronal culture hippocampus human human cell in vivo study male mouse nerve degeneration neurofeedback nonhuman priority journal protein expression protein phosphorylation protein stability rat animal cognition cytology drug effects feedback system gene expression regulation genetic transcription genetics metabolism nerve cell phosphorylation physiology primary cell culture signal transduction tumor cell line Amyloid beta-Peptides Animals Calcium Cell Line, Tumor Cell Survival Cognition Cyclin-Dependent Kinase 5 Cyclin-Dependent Kinase Inhibitor p19 Cytotoxins DNA Damage DNA Repair Feedback, Physiological Gene Expression Regulation Hippocampus Humans Mice Neurons Peptide Fragments Phosphorylation Primary Cell Culture Signal Transduction Transcription, Genetic Zinostatin
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_01674889_v1843_n7_p1309_Ogara
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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