Inhibition of Junín virus replication by small interfering RNAs

Junín virus (JUNV), the etiological agent of the Argentine hemorrhagic fever, has a single-stranded RNA genome with ambisense expression which encodes for five proteins. In previous works we have demonstrated that the Z arenavirus matrix protein represents an attractive target for antiviral therapy....

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Detalles Bibliográficos
Autores principales: Artuso, M.C., Ellenberg, P.C., Scolaro, L.A., Damonte, E.B., García, C.C.
Formato: JOUR
Materias:
Arenavirus
Junín virus
Matrix protein
RNA interference
siRNAs
guanine nucleotide binding protein
small interfering RNA
virus antigen
virus RNA
animal cell
antigen expression
article
controlled study
drug efficacy
drug specificity
drug targeting
genetic transfection
human
human cell
Junin virus
nonhuman
nucleotide sequence
priority journal
protein expression
virus inhibition
virus plaque
virus replication
Animals
Arenaviridae Infections
Base Sequence
Cell Line
Cercopithecus aethiops
Cricetinae
Down-Regulation
Molecular Sequence Data
RNA Interference
RNA, Small Interfering
Sequence Alignment
Vero Cells
Virus Replication
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_01663542_v84_n1_p31_Artuso
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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