The pH of HNO donation is modulated by ring substituents in Piloty's acid derivatives: Azanone donors at biological pH

A group of Piloty's acid (N-hydroxybenzenesulfonamide) derivatives were synthesized and fully characterized in order to assess the rates and pH of HNO (azanone, nitroxyl) donation in aqueous media. The derivatives, with electron-withdrawing and -donating substituents include methyl, nitro, fluo...

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Detalles Bibliográficos
Autores principales: Sirsalmath, K., Suárez, S.A., Bikiel, D.E., Doctorovich, F.
Formato: JOUR
Materias:
Azanone donors
Nitroxyl donors
Piloty's acid
Ring substituents
benzenesulfonamide derivative
phenol derivative
piloty acid derivative
porphyrin
unclassified drug
acidity
aqueous solution
decomposition
density functional theory
electrochemical analysis
electron transport
enthalpy
modulation
pH
pKa
proton transport
review
sensor
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_01620134_v118_n_p134_Sirsalmath
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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