Antiviral activity of A771726, the active metabolite of leflunomide, against Junín virus

The aim of this study was to investigate the effect of A771726, the active metabolite of leflunomide, (CONICET-UBA), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad against the infection with Junín virus (JUNV), agent of Argentine hemorrhagic fever (AHF). The treatment...

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Detalles Bibliográficos
Autores principales:	Sepúlveda, C.S., García, C.C., Damonte, E.B.
Formato:	JOUR
Materias:	A771726 antiviral activity arenavirus host target leflunomide pyrimidine inhibitor dihydroorotate dehydrogenase drug metabolite orotic acid pyrimidine ribavirin teriflunomide uridine virus RNA A-549 cell line animal cell Article cell viability controlled study drug effect drug efficacy drug mechanism drug response drug structure enzyme activity human human cell Junin virus nonhuman real time polymerase chain reaction RNA synthesis treatment outcome virus replication virus strain
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_01466615_v90_n5_p819_Sepulveda
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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