Leptin promotes HLA-G expression on placental trophoblasts via the MEK/Erk and PI3K signaling pathways

Introduction The development of the human haemochorial placenta requires complex regulatory mechanisms to protect invasive trophoblast cells from cytotoxic responses elicited by maternal immune cells. Leptin, the adipocyte derived hormone encoded by the Lep gene, is synthesized by placental trophobl...

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Detalles Bibliográficos
Autores principales: Barrientos, G., Toro, A., Moschansky, P., Cohen, M., Garcia, M.G., Rose, M., Maskin, B., Sánchez-Margalet, V., Blois, S.M., Varone, C.L.
Formato: JOUR
Materias:
HLA-G
Leptin
Placenta
Signal transduction
2 (2 amino 3 methoxyphenyl)chromone
2 morpholino 8 phenylchromone
HLA G antigen
leptin
mitogen activated protein kinase kinase
phosphatidylinositol 3 kinase
protein kinase B
recombinant leptin
antisense oligodeoxynucleotide
protein kinase inhibitor
recombinant protein
antigen expression
Article
choriocarcinoma cell line
controlled study
embryo
explant
female
first trimester pregnancy
gene expression
hormone action
human
human cell
immune evasion
immune response
immunofluorescence
immunomodulation
in vitro study
placenta
priority journal
protein expression
reverse transcription polymerase chain reaction
signal transduction
syncytiotrophoblast
trophoblast
upregulation
Western blotting
adult
antagonists and inhibitors
cell line
chemistry
cytology
drug effects
gene expression regulation
gene silencing
genetics
immunology
metabolism
pregnancy
reproduction
third trimester pregnancy
tissue culture technique
Adult
Cell Line
Female
Gene Expression Regulation, Developmental
Gene Silencing
HLA-G Antigens
Humans
MAP Kinase Signaling System
Oligodeoxyribonucleotides, Antisense
Phosphatidylinositol 3-Kinase
Placentation
Pregnancy
Pregnancy Trimester, First
Pregnancy Trimester, Third
Protein Kinase Inhibitors
Recombinant Proteins
Signal Transduction
Tissue Culture Techniques
Trophoblasts
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_01434004_v36_n4_p419_Barrientos
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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