p21 modulates threshold of apoptosis induced by DNA-damage and growth factor withdrawal in prostate cancer cells

Current therapy for advanced prostate cancer is largely based on androgen deprivation and is mostly palliative because all patients eventually relapse with androgen-independent disease. Doxorubicin (Dx), an anthracycline used commonly as a chemotherapeutic agent in relapsed prostate cancer, is a str...

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Detalles Bibliográficos
Autores principales: Martinez, L.A., Yang, J., Vazquez, E.S., Rodriguez-Vargas, M.D.C., Olive, M., Hsieh, J.-T., Logothetis, C.J., Navone, N.M.
Formato: JOUR
Materias:
androgen
anthracycline derivative
antineoplastic agent
antisense oligonucleotide
caspase
DNA
doxorubicin
growth factor
protein p21
protein p53
virus protein
Adenovirus
advanced cancer
apoptosis
article
cancer cell culture
cancer chemotherapy
cancer growth
cancer recurrence
cancer survival
cell cycle
cell kinetics
concentration response
controlled study
DNA damage
down regulation
drug sensitization
enzyme activation
hormonal regulation
hormone inhibition
human
human cell
knockout gene
nonhuman
oxidative stress
palliative therapy
priority journal
prostate cancer
protein expression
protein function
protein induction
regulatory mechanism
transactivation
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_01433334_v23_n8_p1289_Martinez
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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